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High Quality 4-（HYDROXYMETHYL)-5-METHYL-1,3-DIOXOL-2-ONE Intermediate 91526-18-0 Chinese Supply

Description

4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one is a reagent used in organic synthesis, particularly for the introduction of the non-chiral (oxodioxolenyl)methyl carbamate group to active pharmaceutical ingredients (APIs) to afford the corresponding pro-drug. The pro-drug helps to increase the bio-availability of the active drug which is generated in vivo by a base catalysed decomposition process that destroys the 1,3-dioxol-2-one ring. A high-profile example of this is the hypertension drug Alizsartan medoxomil. 4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one can be reacted with oxalyl chloride to afford (5-methyl-2-oxo-1,3-dioxol-4-yl)methyloxyoxayl chloride which provides for an alternative approach to introduce the (oxodioxolenyl)methyl carbamate group.

Properties

	Common Name	4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one
	CAS Number	91526-18-0	Vapour Pressure	0.0±0.9 mmHg at 25°C
	Density	1.4±0.1 g/cm3	Boiling Point	213.8±32.0 °C at 760 mmHg
	Molecular Formula	C5H6O4	Molecular Weight	130.099
	Index of Refraction	1.494	Flash Point	92.8±18.6 °C
	PSA	63.58	LogP	1.07